Naphthoate synthase
Witryna5 kwi 2011 · Note: The hydrogencarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria. WitrynaThis enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), …
Naphthoate synthase
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The enzyme 1,4-dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) catalyzes the sixth step in the biosynthesis of phylloquinone and menaquinone, the two forms of vitamin K. In E. coli, 1,4-dihydroxy-2-naphthoyl-CoA synthase, formerly known as naphthoate synthase, is encoded by menB and uses O … Zobacz więcej MenB is part of the crotonase fold super family, named after the crotonase fold in their structure. The systematic name for MenB is 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing). Other common … Zobacz więcej MenB is composed of two hexamers in an asymmetric unit, these hexamers are each composed of two trimers in an eclipsed arrangement. Each sub unit of the hexamers has three C terminal alpha helices, and a N terminal spiral core. These sub units come … Zobacz więcej MenB does not require any cofactors to catalyze the reaction. In the organism Escherichia coli three inhibitors exist: 1-hydroxy-2-naphthoyl-CoA, 2,3-dihydroxybenzoyl-CoA, and 2,4-dihydroxybenzoyl-CoA. Zobacz więcej It was originally thought that the product of this reaction had an oxygen where the SCoA currently resides, however; new research has shown that MenB only catalyzes the … Zobacz więcej Homologous genes MenB exist in many different organisms, such as; Galium mollugo, Geobacillus kaustophilus, MenB is only … Zobacz więcej Witryna13 kwi 2024 · Changes in gene expression by q-RT-PCR analysis at different stages in menaquinone and mevalonate pathway biosynthesis: A MenA,1,4-dihydroxy-2-naphthoate octaprenyltransferase, MenB, naphthoate synthase, MenC, osuccinylbenzoate-CoA synthase, MenD, 2-succinyl-6- hydroxy-2,4-cyclohexadiene …
Witryna1 paź 2005 · The enzyme naphthoate synthase (MenB) from M. tuberculosis has been expressed in Escherichia coli, purified and crystallized both as the native enzyme and in complex with naphthoyl-CoA. WitrynaThis enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone (vitamin K1 in plants), and many plant pigments. The coenzyme A group is subsequently removed from the product by EC 3.1.2.28 .
WitrynaNaphthoate synthase (MenB, also known as 1,4-dihydroxy-2-naphthoyl-CoA synthase) is involved in the synthesis of 1,4-dihydroxy-2-naphthoate, a branch … Witryna8 kwi 2009 · 2.15 Angstrom Resolution Crystal Structure of Naphthoate Synthase from Salmonella typhimurium. PDB DOI: 10.2210/pdb3H02/pdb; Classification: LYASE; Organism(s): Salmonella enterica subsp. enterica serovar Typhimurium; Expression System: Escherichia coli; Mutation(s): No ; Deposited: 2009-04-08 Released: 2009-04 …
Witryna1 sty 2013 · Naphthoate synthase (MenB/NS) catalyses the essential formation of the second aromatic ring in phylloquinone biosynthesis, i.e., the conversion of o -succinylbenzoyl-coenzyme A to 1,4-dihydroxy-2 …
Witryna17 sty 2007 · The aerobic Gram-positive bacterium Geobacillus kaustophilus is a bacillus species that was isolated from deep-sea sediment from the Mariana Trench. 1,4-Dihydroxy-2-naphthoate (DHNA) synthetase plays a vital role in the biosynthesis of menaquinone (vitamin K 2) in this bacterium. DHNA synthetase from Geobacillus … dollar tree tiny containersWitryna17 maj 2024 · The expression patterns of two isoforms of naphthoate synthase followed opposite trends in different tissues (Fig. 8). Thus, we conclude that MEP and isochorismate pathways for anthraquinone biosynthesis were dominant in the leaf tissue in our study. The sterols and terpenoids biosynthesis also shares the MEP pathway; … dollar tree town centerWitrynaNaphthoate. The naphthoate portion (22) of NCS chromophore is the most important site for binding to apoNCS and DNA intercalation. From: Frontiers in … dollar tree town centre dr cornelia gaWitryna18 cze 2024 · MqnD catalyzes the conversion of cyclic dehypoxanthine futalosine ( 6) to 5,8-dihydroxy-2-naphthoic acid ( 7) and an uncharacterized product. This study describes a chemoenzymatic synthesis of 6. This synthesis achieved a 2-fold yield enhancement by using titanium (III) citrate as the reducing agent and another 5-fold yield enhancement … fake credit card security code visaWitryna18 cze 2024 · MqnD catalyzes the conversion of cyclic dehypoxanthine futalosine ( 6) to 5,8-dihydroxy-2-naphthoic acid ( 7) and an uncharacterized product. This study … fake credit cards detailsWitryna28 lip 2024 · In this regard, we have identified naphthoate synthase (1,4‐dihydroxy‐2‐naphthoyl‐CoA synthase, EC: 4.1.3.36; DHNS) as an anti‐E. faecalis target, as it is an essential enzyme for menaquinone (vitamin K 2) synthetic pathway in the bacterium. Thus, inhibiting naphtholate synthase may consequently inhibit the … dollar tree towanda paWitryna1 gru 2010 · Naphthoate synthase is a key enzyme in the production of menaquinone. In Escherichia coli, menaquinone is predominant under anaerobic culture conditions … fake credit cards ibanking