WebJul 3, 2005 · Dihydrodipicolinate synthase (E. coli)- mutant R138A. In plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate, a reaction catalyzed by dihydrodipicolinate synthase (DHDPS, EC 4.2.1.52). WebDihydrodipicolinate synthase (DHDPS) catalyses the aldol-like condensation of pyruvate and L-aspartate beta semi-aldehyde (S-ASA). It is an enzyme involved in the lysine biosynthetic pathway of procaryotes, some Phycomycetes and higher plants. Since this pathway is not present in animals, pathway members such as DHDPS have become …

RCSB PDB - 1XXX: Crystal structure of Dihydrodipicolinate Synthase ...

WebThe substrate of the DapB catalyzed reaction, dihydrodipicolinate (DHDP), is the unstable product of the previous enzyme, the dihydrodipicolinate synthase (DapA or DHDPS). … WebIn plants and bacteria, the branch point of (S)-lysine biosynthesis is the condensation of (S)-aspartate-beta-semialdehyde [ (S)-ASA] and pyruvate, a reaction catalyzed by dihydrodipicolinate synthase (DHDPS, EC 4.2.1.52) [8]. Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase [8]. buckingham va crime

RCSB PDB - 1DHP: DIHYDRODIPICOLINATE SYNTHASE

WebMay 1, 2000 · Dihydrodipicolinate synthase (DHDPS) catalyzes the first step in the biosynthetic pathway for production of l-lysine in bacteria and plants. The enzyme has received interest as a potential drug target owing to the absence of the enzyme in mammals. WebJun 1, 1993 · Similarly, plants transformed with a chimeric gene encoding a bacterial dihydrodipicolinate synthase were selected for resistance to the toxic lysine analog S … WebDec 11, 2012 · This reaction, which is the first that differs from the ectoine biosynthesis pathway, is catalyzed by the dihydrodipicolinate synthase. Three copies of the corresponding gene were identified ( dapA1 , Hbhal_2387, dapA2 , Hbhal_3091, dapA3 , Hbhal_5017) which may indicate its critical role in the biosynthesis. credit checks for car rentals