WebFolate deficiency can cause severe birth defects called neural tube defects. Neural tube defects include spina bifida and anencephaly . Folate deficiency can also increase your … WebWhat happens when folic acid given with phenytoin? The supplementation of folic acid to folate-deficient patients taking phenytoin has been shown to result in lowered serum concentrations of phenytoin, and possibly loss of control of the seizure disorder. ... Folate deficiency can cause anemia. Anemia is a condition in which you have too few RBCs.
Antiepileptic drugs interact with folate and vitamin B12 …
WebPhenytoin — levels may be reduced by 16–50% if taken concurrently with folic acid. Monitor phenytoin concentrations and adjust the dose accordingly. Primidone — levels … WebPhenytoin and other antiepileptic drugs, oral contraceptives, and antimalarial drugs may cause folate deficiency by inhibiting folate conjugates in the intestinal wall. The antimetabolites methotrexate and trimethoprim inhibit folate reduction and lead to a megaloblastic anemia with prolonged use. bungalows for sale stockton lane york
Folate Deficiency: Symptoms, Complications, and More
WebA case of a patient who developed symptomatic phenytoin-induced folic acid deficiency is reported. Folate supplementation of 5 mg/d was followed by a decrease of serum … WebPhenytoin has been associated with drug-induced gingival enlargement (overgrowth of the gums), probably due to above-mentioned folate deficiency; indeed, evidence from a randomized controlled trial suggests that folic acid supplementation can prevent gingival enlargement in children who take phenytoin. [32] WebJun 27, 2024 · Untreated folic acid deficiency can lead to megaloblastic anemia and pancytopenia. In addition, it can cause glossitis, angular stomatitis, and oral ulcers [2]. Neuropsychiatric manifestations, including depression, irritability, insomnia, cognitive decline, fatigue, and psychosis, are also known to occur with folic acid deficiency . bungalows for sale st nicholas park